Long-Acting/Extended Release (LA/ER) Antiretroviral Research Resource Program Investigator Meeting & Annual Workshop - 2019

Date: 
3/13/19

Sunday, March 3, 2019
Grand Hyatt Seattle Hotel
SEATTLE

 

REGISTRATION:

Carl Dieffenbach, Director, Division of AIDS, NIH
Welcome!
Charles Flexner, Johns Hopkins University
Where Will We LEAP to Next?!
Workshop Overview  
[audio-only/slide]

PLENARY SESSION: Current Status of Existing Technologies:

Peter Williams, Janssen
Clinical Development of LA Rilpivirine
[audio-only/slide]

William Spreen, ViiV Healthcare
Clinical Development of LA Cabotegravir
[audio-only/slide
 
Jay Grobler, Merck
Current Status of the Merck LA/ER Pipeline
[audio-only/slide]
    
Jim Zheng, Gilead Sciences
Preclinical profile of a novel capsid inhibitor
[audio-only/slide]
    
Susan Swindells, University of Nebraska Medical Center
LEAP TB:  Update from the LEAP Working Group on Development of Long-Acting Approaches to the Treatment of Tuberculosis
[audio-only/slide]

Marco Siccardi, University of Liverpool
Update from the LEAP Modeling and Simulation Core: Using Physiologically-based Pharmacokinetic and Pharmacodynamic Modelling to Assess Drug Candidates
[audio-only/slide]

Melissa Davey-Rothwell, Johns Hopkins University, LEAP Systematic Reviews Core
Use of Systematic Reviews to Inform the Development of LA-ER Drug Delivery Products for Children, Adolescents, and Pregnant Women
[audio-only/slide]

PLENARY SESSION: Novel Approaches to LA/ER Drug Delivery:

Babafemi Taiwo, Northwestern University
Combining Cabotegravir-LA and VRC01-LS for Viral Suppression in HIV-1-infected Adults
[audio-only/slide]

Kimberly Struble, FDA
Getting to Phase 2 Without an Oral Partner Formulation: Regulatory Perspective
[audio-only/slide]

Marc Baum, Oak Crest Institute
Tenofovir Alafenamide Subcutaneous Implant: Transition from Preclinical to Early Stage Clinical Evaluation
[audio-only/slide]

Benson Edagwa, University of Nebraska Medical Center
Nanoformulation of Novel NRTI Prodrugs for LA Delivery
[audio-only/slide]

Lut Van Damme, Bill & Melinda Gates Foundation
Nanoformulation of Novel NRTI Prodrugs for LA Delivery
[audio-only/slide]
 
FOCUS GROUP REPORTS:

GROUP 1:  Raphael Landovitz & Richard Koup, Co-Chairs; Jeff Jacobson, Rapporteur
Partnering Long-acting Broadly Neutralizing Antibodies with Small Molecule Formulations: What Are the Issues?
[audio-only/slide]

GROUP 2:  Paul Domanico & Catherine Chappell Co-Chairs; Andy Kaytes, Rapporteur
Clinical Development of Antiretroviral Implants: Identifying Barriers & Knowledge Gaps
[audio-only/slide]

GROUP 3:  Terrance Blaschke & Elaine Abrams, Co-Chairs; Craig Hendrix, Rapporteur
Best Practices in the Management of Non-adherent Patients: Defining ‘Forgiveness’ for LA Regimens
[audio-only/slide]

GROUP 4:  Carmen Perez Casas & Meg Doherty, Co-Chairs; Polly Clayden, Rapporteur
Transitioning LA/ER Formulations to a Generic Marketplace for LMICs
[audio-only/slide]